傳統中藥抗氧化成分與男性不孕精液品質的相關性

溫晨越¹、李佳榮²、張炯宏³、林仁泰¹、余家政¹

¹高雄榮民總醫院 外科部 泌尿外科; ²高雄榮民總醫院 婦產部; ³台南市立醫院(委託秀傳醫療社團法人經營) 傳統醫學部

The relationship between antioxidative ingredients of traditional Chinese medicine and semen quality in men with infertility

Chen-Yueh Wen¹, Chia-Jung Li², Chiung-Hung Chang³, Jen-Tai Lin¹, Chia-Cheng Yu¹

¹Divisions of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

²Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

³Department of Traditional Chinese Medicine, Tainan Municipal Hospital (Managed By Show Chwan Medical Care Corporation), Tainan, Taiwan

Background:

The problem of infertility has always been a concern in the global aging, and it is also a significant clinical problem. In this study, we designed further large-scale randomized controlled trials to investigate the effects of non-toxic antioxidative traditional Chinese medicine (TCM) on semen quality.

Materials and Methods:

We analyze retrieved data of infertile men that were treated with TCM from January 2013 to December 2021. The 125 patients received TCM therapies for 3 and 6 months. Semen quality analysis in accordance with the WHO criteria is an essential step in the evaluation of male fertility status. Associations between the semen parameters and body mass index, smoking status, alcohol use, duration of infertility, and age were also analyzed.

Results:

We found that the inferior sperm quality in TCM treatment group was significantly improved, but not in the untreated group. There were nearly 20.80%, 40.80%, and 29.84% change better for semen concentration, overall motility and morphology after 3 months TCM intervention, respectively, and about 18.18%, 45.45% and 34.85% after 6 months of TCM treatment, according to the 2010 WHO guidelines.

Conclusion:

In summary, we found that antioxidative TCM profoundly improve semen quality in infertile patients including increasing semen volume, sperm concentration, normal sperm morphology and total motility compared to untreated groups. In TCM group, semen quality parameters significantly improved after 3 months treatment and semen quality could maintain or get better at 6 months treatment. Furthermore, no adverse reactions were found in this study. These results suggest that antioxidative TCM is an effective treatment and may provide a choice for infertile patients.