高雄醫學大學 醫學院 臨床醫學研究所1 ; 高雄醫學大學附設醫院 泌尿部2;
高雄醫學大學 3; 高雄市立大同醫院 泌尿科4
Does COVID-19 Vaccine Deteriorate Storage Lower Urinary Tract Symptoms?
Yu-Chen Chen1,2, Yin-Chi Liang3, Shuo-Jung Ho3, Hao-Wei Chen1,2,4, Yung-Shun Juan1,2, Wen-Jeng Wu1,2.
1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. ; 2Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. ; 3Kaohsiung Medical University. ; 4 Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
Purpose: Few studies reported of the storage lower urinary tract symptoms (LUTS) as the urinary adverse events (AEs) after vaccine for coronavirus disease 2019 (COVID-19). Therefore, this study aims to investigate the storage LUTS before and after the first dose of COVID-19 vaccine. We also assessed the association between overactive bladder (OAB) and the worsening of storage LUTS following COVID-19 vaccine.
Materials and Methods: A cross-sectional survey-based study was conducted in a third-level hospital in Taiwan between October 2021 and January 2022 using the online questionnaires, which included the validated pre-vaccinated and post-vaccinated Overactive Bladder Symptom Score (OABSS). Diagnosis of OAB was made based on the pre-vaccinated OABSS. The deterioration of storage LUTS, assessed as the increased score of OABSS following vaccine, and the association between OAB was analyzed.
Results: Out of the 889 participating subjects, 595 (66.9%) were females, 71 (8.0%) were OAB. 119 (13.4%) subjects experienced the worsening storage LUTS following vaccine. Compared to non-OAB group, OAB was significantly associated with an increased risk of worsening urinary urgency (14.1% vs 5.4%, p=0.030), urinary frequency (11.3% vs 5.0%, p=0.027), and seeking the medical help due to the deterioration of storage LUTS (16.9% vs 5.2%, p<0.001) after vaccination. Furthermore, OAB group have significantly greater change of scores in OABSS-urgency (p=0.003), OABSS-frequency (p=0.025) and total OABSS (p=0.014) after vaccination, compared to non-OAB group. After adjusting the demographic factors, including age, gender, comorbidities, types of vaccines, multivariate regression revealed that the only risk factor of the deterioration of storage LUTS was the pre-vaccinated OAB status (OR=2.55; 95 % CI=1.39-4.69; p=0.003).
Conclusions: Storage LUTS can be deteriorated after COVID-19 vaccine. OAB was significantly associated with higher risk of worsening storage LUTS, especially urinary urgency and frequency, after COVID-19 vaccine. Worsening of the storage LUTS after vaccination should be monitored more actively in OAB patients. Further prospective studies are needed to prove causal association between vaccine and the worsening urinary symptoms after vaccination.