先天性結締組織疾病患者罹患腹股溝疝氣之風險研究

張顥瀚¹⁴、李經家¹²⁴、李香瑩¹²³⁴、陳建翰⁵⁶

高雄醫學大學附設中和醫院 泌尿部¹、高雄醫學大學醫學系 泌尿學科²、高雄市立大同醫院 泌尿科³、高雄醫學大學 臨床醫學研究所⁴、義大醫院 外科部⁵、義守大學 醫學院⁶

Congenital Collagenopathy Increased the Risk of Inguinal Hernia－A Longitudinal Cohort Study

Hao-Han Chang^1,4, Ching-Chia Li^1,2, Hsiang-Ying Lee^1,2,3,4, Jian-Han Chen^5,6

1Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

2Department of Urology, School of Medicine, College of Medicine, KaohsiungMedical University, Kaohsiung,

3Urology Department, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.

4Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung MedicalUniversity, Kaohsiung, Taiwan

5Division of General Surgery, E-Da Hospital, Kaohsiung, Taiwan.

6School of Medicine, College of Medicine, I-Shou University,Kaohsiung, Taiwan..

Purpose:

The aim of this study is to explore whether male patients diagnosed of congenital collagen diseases had higher risk of occurrence inguinal hernia than patients who do not had these diseases.

Materials and Methods: Data were collected from National Health Insurance Research Database (NHIRD) of Taiwan retrospectively. 1801 male patients who diagnosed of congenital collagen disease by using ICD-9 CM diagnostic code was the study cohort, and in the other hand, after propensity score matching, 6493 man without congenital collagen disease were enrolled as control group. The primary endpoint was receiving inguinal hernia repair during observation period.

Results: During the fifteen-year follow-up period, the incidence rate of inguinal hernia in collagen cohort was 2.237 times than the control group (95% CI:1.646-3.291, p < 0.001). Furthermore, this phenomenon also presented in patient younger than 18 (HR:3.040 95% CI: 1.819-5.083, p < 0.001) and in age 18-80 (HR: 1.909, 95% CI: 1.186-3.073, p < 0.001).

Conclusions: Asian men, regardless of age, with congenital collagen disease are at the risk of developing inguinal hernia. Detailed physical examination and well patient education should be performed while facing these patients.