咀嚼檳榔與引起腎結石的風險相關

吳冠賢^1,2、張君愷^1,2、李佳殷³、張祝芬⁴、李永進^1,2、詹鎮豪^1,2、王巽玄^1,2、沈榮宗¹、曹曜軒^1,2、黃書彬^2,5,6,7、耿俊閎^1,2,5,6,7,8*

¹高雄市立小港醫院 泌尿科；²高雄醫學大學 附設醫院泌尿部，³附設醫院精神醫學部；⁴慈濟大學 物理治療學系；⁵高雄醫學大學 醫學院醫學系泌尿科，⁶醫學院臨床醫學研究所，⁷環境職業醫學博士學位學程，⁸環境醫學研究中心

Betel Nut Chewing Is Related to the Risk of Kidney Stone Disease

Kuan-Hsien Wu ^1,2, Chun-Kai Chang ^1,2, Jia-In Lee ³, Chu-Fen Chang ⁴, Yung-Chin Lee ^1,2, Jhen-Hao Jhan ^1,2, Hsun-Shuan Wang ^1,2, Jung-Tsung Shen ¹, Yao-Hsuan Tsao ^1,2, Shu-Pin Huang ^2,5,6,7, Jiun-Hung Geng ^1,2,5,6,7,8*

¹ Department of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan

² Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

³ Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

⁴ Department of Physical Therapy, Tzu Chi University, Hualien, Taiwan

⁵ Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

⁶ Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

⁷ Ph.D. Program in Environmental and Occupational Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

⁸ Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Abstract

Background: Betel nut chewing injures bodily health. Although, the relationship between betel nut chewing and kidney stone disease (KSD) is unknown.

Materials and Methods: We analyzed 43,636 men from Taiwan Biobank. We divided them into two groups on the status of betel nut chewing, the never-chewer and ever-chewer groups. Self-reported diagnosed KSD was defined as the subject’s medical history of KSD in the questionnaire. Logistic regression was used to analyze the association of betel nut chewing and the risk of KSD.

Results: The mean age of subjects in the present study was 50 years, and 16% were ever-chewers. KSD was observed in 3759 (10.3%) and 894 (12.6%) participants in the group of never-chewer and ever-chewer groups, respectively. Higher risk of KSD was found in participants with betel nut chewing compared with to without betel nut chewing (odds ratio (OR), 1.094; 95% confidence interval (95% CI), 1.001 to 1.196). Furthermore, the daily amounts of betel nut chewing >30 quids was associated with a more than 1.5-fold increase (OR, 1.571; 95% CI, 1.186 to 2.079) in the odds of KSD.

Conclusions: Our study suggests that betel nut chewing is associated with the risk of KSD and warrants further attention to this problem.