維持性與誘導性膀胱內化療灌注在非肌肉侵襲性膀胱癌的比較
陳正宇、曾文歆、黃冠華
奇美醫療財團法人永康奇美醫院外科部泌尿外科
The Comparison of Maintenance and Induction Intravesical Chemotherapy in the Treatment of Non-Muscle Invasive Bladder Cancer
Cheng-Yu Chen, Weng-Shin Tzeng, Steven Kuan-Hua Huang
Division of Urology, Department of Surgery, Chi-Mei Medical Center, Tainan, Taiwan
Purpose: We compared the utilization of maintenance and induction intravesical chemotherapy (IVC) in the treatment of non-muscle invasive bladder cancer (NMIBC) in the aspect of recurrence, progression, and survival.
Materials and Methods: A total 45 maintenance IVC patients and 50 induction IVC patients were enrolled. They received whether Epirubicin or Mitomycin-c in protocol. We analyzed the recurrence-free survival(RFS), overall survival(OS) and complication in the follow-up of 4 years.
Results: In comparison of maintenance and induction IVC, there was no significant difference in recurrence-free survival (p=0.82) and overall survival (p=0.45). No statically significant difference of complication (p=0.67) after IVC was found between the two groups.
Conclusions: Current guidelines remain controversial type and regimen for IVC of NMIBC patients, though maintenance therapy is a standard way of BCG instillation. In our study, there was no significant between maintenance and induction therapy in the aspect of RFS, OS and complication.