腎臟大細胞神經內分泌癌合併高惡性度泌尿上皮癌及Virchow’s淋巴結轉移:病例報告及文獻回顧
何明錫1、陳逸軒1,2、林仁泰1、蔡政諭1、余家政1,2,3、吳東霖1
1高雄榮民總醫院外科部泌尿外科
2國防醫學中心三軍總醫院外科部泌尿外科
3大仁科技大學藥學系
Primary Large Cell Neuroendocrine Carcinoma of the Kidney with coexisting High-Grade Urothelial Carcinoma and Virchow’s Node Metastasis: A Case Report and Literature Review
Ming-Xi He1、I-Hsuan Chen,2, Yin-Shen Chen1, Jen-Tai Lin1, Jeng-Yu Tsai1, Chia-Cheng Yu1,2,3, Tony Tong-Lin Wu1,3
1 Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital
2 Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center
3 Department of Pharmacy, Tajen University
Abstract:
Primary large cell neuroendocrine carcinomas of the kidney are extremely rare, and distant metastases are scarcely reported. Here, we report a case of a 68-year-old man who presented with hematuria and was found to have an enlarged neck mass and a huge mass at the left kidney. Radical nephroureterectomy with bladder cuff excision and paraaortic lymphadenectomy was performed. A diagnosis of primary large cell neuroendocrine carcinoma with coexisting high-grade urothelial components was rendered. Besides, the fine-needle aspiration cytology reported neuroendocrine metastasis. In this report, the clinical, cytological, histological, and immunohistochemical features of this case are described, and a review of the literature about this neoplasm is presented.