在中台灣基質金屬蛋白酶-9基因型與腎細胞癌風險的關聯性

廖丞晞^1,2,3,4 張文馨^2,3 吳錫金⁵ 蔡佳紋^2,3 包大靝^2,3,4

¹國軍臺中總醫院外科部泌尿外科; ²中國醫藥大學生物醫學研究所; ³泰瑞法克斯癌症研究室; ⁴國防醫學院臨床醫學研究所; ⁵中國醫藥大學附設醫院泌尿外科

The Association of Matrix Metalloproteinase 9 Genotypes on Renal Cell Carcinoma Risks in mid-Taiwan

Cheng-Hsi Liao^1,2,3,4 , Wen-Shin Chang^2,3 , Hsi-Chin Wu⁵, Chia-Wen Tsai^2,3,and Da-Tian Bau^1,2

¹ Division of Urology, Department of Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.;

² Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;

³ Terry Fox Cancer Research Laboratory;

⁴ Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, R.O.C.;

⁵ Department of Urology, China Medical University Hospital, Taichung, Taiwan, R.O.C.;

Purpose: The expression of matrix metalloproteinase 9 (MMP9) is elevated in various renal diseases, including renal cell carcinoma. However, the role of MMP9 genotype in this context remains unclear. This study aimed to investigate the association between MMP9 promoter rs3918242 genotypes and the risk of renal cell carcinoma.

Materials and Methods: The MMP9 rs3918242 genotypes of 118 patients with renal cell carcinoma and 590 healthy subjects were determined using the polymerase chain reaction-restriction fragment length polymorphism method.

Results: The results indicated that individuals carrying the CT or TT genotype of MMP9 rs3918242 did not exhibit an increased risk of renal cell carcinoma compared to wild-type CC carriers (odds ratio=1.20 and 2.68, 95% confidence interval=0.75-1.92 and 0.89-8.03; p=0.5270 and 0.1420, respectively). However, individuals with the CT and TT genotypes had a higher prevalence of renal cell carcinoma than those with the CC genotype when they also had hypertension (p=0.0010), diabetes (p=0.0010), or a family history of cancer (p0.05). Additionally, no correlation was found between MMP9 rs3918242 genotype and the risk of renal cell carcinoma in individuals with smoking or alcohol consumption habits.

Conclusions: Carrying the T allele for MMP9 rs3918242 may predict a higher risk of renal cell carcinoma among individuals diagnosed with hypertension, diabetes, or with a family history of cancer.