TALDO1 蛋白質的過度表現是上泌尿道上皮癌預後不佳的因子
吳奕儒1、李怡琛2、李威明3,4,5、徐偉齊6、林慧惠3,6、張玲麗6,7、詹鎮豪8,9、吳文正3,4,6、李經家3,4、李香瑩3,4,6、葉信志3,4、柯宏龍3,4,6
高雄醫學大學 醫學系1 、解剖學科2、泌尿學科4、醫學研究所6、微生物與免疫學科7
高雄醫學大學附設泌尿部3、衛生福利部屏東醫院泌尿科5、小港醫院泌尿科8
High Transaldolase 1 (TALDO1) expression predicts poor survival of upper tract urothelial carcinoma patients
Yi-Ru Wu1, Yi-Chen Lee 2, Wei-Ming Li 3,4,5, Wei-Chi Hsu6, Hui-Hui Lin3,6, Lin-Li Chang6,7, Jhen-Hao Jhan 9, Wen-Jeng Wu 3,4,6, Ching-Chia Li 3,4, Hsiang-Ying Lee3,4,6, Hsin-Chih Yeh3,4, Hung-Lung Ke3,4,6
1School of Medicine, 2Department of Anatomy, 4Department of Urology, 7Department of Microbiology, School of Medicine, College of Medicine; 5 Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung; 6 Graduate Institute of Medicine, College of Medicine; 3 Department of Urology, Kaohsiung Medical University Hospital; 8 Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University
Purpose:
Upper tract urothelial carcinoma (UTUC) is a rare tumor with extraordinarily different feature between Eastern and Western countries. Transaldolase 1 (TALDO1) is a rate-limiting enzyme involved in the pentose phosphate pathway. The importance of human TALDO1 was involved in different autoimmune diseases and other malignancies. However, the function of TALDO1 in UTUC has not been investigated. This study evaluates the clinical significance of TALDO1 expression in UTUC.
Materials and Methods:
TALDO1 expression was examined in 115 paraffin-embedded tumor samples from patients with UTUC by immunohistochemistry staining. An analysis was performed to identify the association between TALDO1 expression and different clinicopathologic variables.
Results:
In overall survival analysis of TCGA Database, high TALDOI expression had shorter survival in Bladder cancer patient (P=0.0048). In UTUC, TALDO1 high expression is significantly associated with stage (P <0.011), distant metastasis (P <0.023), cancer recurrence (P <0.003) and cancer death (P <0.003). In univariable and multivariable analysis, we found that late stage (III/IV) and high TALDO1 expression are both independent factors for the disease-free survival and cancer-specific survival.
Conclusion:
In our study, increased TALDO1 expression in UTUC is significant correlated with advanced stage (III/IV), cancer recurrence, distant metastasis and cancer death. The high TALDO1 expression also can be as a predictor for poor survival of UTUC patients. Further study is necessary to investigate the role of TALDO1 in carcinogenesis of UTUC.