肥胖指標與腎臟結石之相關性

耿俊閎^1,2,3,4、李明儒^2,3,4

¹ Division of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA；²高雄市立小港醫院 泌尿部；
³高雄醫學大學附設醫院 泌尿部；⁴高雄醫學大學；

Obesity-Related indices and Its Association with Kidney Stone

Jiun-Hung Geng^1,2,3,4、Ming-Ru Lee^{, 2,3,4}

¹ Division of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA；²Department of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan；³Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan；⁴Kaohsiung Medical University, Kaohsiung, Taiwan

Purpose:

This study aims to explore the relationship between kidney stones and various obesity-related indices.

Materials and Methods:

A total of 121,605 participants in the Taiwan Biobank from December 2008 to February 2020 were analyzed. The association between self-reported history of kidney stones and 11 obesity-related indices, including body mass index (BMI), waist circumference, waist-to-height ratio, waist-to-hip ratio, body shape index, abdominal volume index, body adiposity index, body roundness index, conicity index, visceral adiposity index, and triglyceride glucose index was examined in the cross-sectional analysis. In addition, the risk of developing incident kidney stones was analyzed in a longitudinal cohort of 25,268 participants without kidney stones at baseline, which was a subset of the main cohort.

Results:

Of all participants, 43,710 (35.9%) were men. Overall, 10.7% of the men and 4.0% of the women had kidney stones. Participants with kidney stones were more likely to be older, have higher blood pressures, higher levels of uric acid, hemoglobin A1C, fasting glucose, total cholesterol, triglyceride, higher values of obesity-related indices, and a lower level of estimated glomerular filtration rate compared to those without kidney stones. Multivariate-adjusted logistic regression showed that all obesity-related indices were significantly associated with kidney stones in both men and women. During a mean follow-up of 47 months, kidney stones occurred in 642 (2.5%) participants. Multivariable Cox analysis revealed that the risk of developing kidney stones was higher in participants with higher BMI, waist circumference, waist-to-height ratio, waist-to-hip ratio, abdominal volume index, body adiposity index and body roundness index.

Conclusions:

We found several obesity-related indices were associated with a higher prevalence of kidney stones as well as development of incident kidney stones, which could be used as relevant assessment tools for kidney stones in clinical practice.