血中維他命D濃度與女性尿失禁之相關性 - 統合分析

許志呈、林毓庭、溫玉清、李良明、林克勳、林雍偉、蕭志豪、石宏仁、許軒豪、賴宗豪

臺北市立萬芳醫院 泌尿科

Serum vitamin D levels in females with urinary incontinence: a meta-analysis of observational trials

Chih-Chen Hsu, Allen Yu Ting Lin, Yu-Ching Wen, Liang-Ming Lee, Ke-Hsun Lin, Yung-Wei Lin, Chi-Hao Hsiao, Hung-Jen Shih, Syuan-Hao Syu, Chung-Howe Lai

Department of Urology, Wan Fan Hospital, Taipei Medical University, Taipei, Taiwan

Purpose:

The association of vitamin D deficiency with female urinary incontinence is unclear. This study is to determine the association of vitamin D deficiency with female urinary incontinence.

Material and Methods:

We conducted a systematic literature search up to 5 October 2020 in the PubMed, EMBASE, Cochrane Library Trials Register, and Google Scholar databases based on the following search terms: “Urinary incontinence” AND “vitamin D”. Nonhuman studies were excluded. There was no language restriction. Cohort studies and case-control studies that reported urinary incontinence as an outcome and vitamin D levels in both the urinary incontinence group and the control group are the main selection criteria.

Results:

Two cohort studies, four case-control studies and five cross-sectional studies were included in the qualitative synthesis. Two cohort studies and one cross-sectional study, with a total of 2501 females, were included in the meta-analysis. Heterogeneity among the three studies was not observed (I2= 0.0%, P =0.69). All pooled analyses were based on fixed-effects models. No difference in vitamin D level was observed between the urinary incontinence group and the control group (mean difference 0.07 ng/mL; 95% confidence interval (CI) -0.57-0.72, P= 0.81, I2=0%).

Conclusion:

Adult females with urinary incontinence did not have lower serum vitamin D levels than control females.