Tumor marker oreintated chemotherapy in cancer of unknown primary site: a case report and literature review
Yu-De Wang, Chao-Hsiang Chang, Chi-Rei Yang
Department of Urology, China Medical University Hospital, Taichung, Taiwan
A case of a 56-year-old woman, who presented with acute abdomen, was diagnosed retroperitoneal poorly differentiated carcinoma of unknown primary site without ovarian involvement. We encountered failure attempt of tumor excision initially. In spite of a primary lesion was not confirmed, we performed tumor maker (CA-199) orientated chemotherapy with the regimen of carboplatin and paclitaxel according to tumor markers and pathological findings.
The size of main tumor decreased remarkably, and retroperitoneal dissection was done successfully after then. Most patients with cancer of unknown primary origin have a very poor prognosis because it is difficult to select appropriate treatment. Tumor marker provide not only as a tool for monitoring but also a guide for chemotherapy regiment. Tumor marker orientated chemotherapy makes operation more feasible and achieves better diagnosis and treatment, as in the case describe here.