The impact of pseudephedrine on lower urinary tract symptoms in male patients without concomitant voiding dysfunction
I-Hung Shao, Hueih-Shing Hsu, Shyh-Chyi Chang, Hsu-Hsiang Wang, Heng-Chang Chuang, Yuan-Yun Tam1
Division of Urology, Poh-Ai Hospital, Lotung, Yilan; Division of Otolaryngology, Poh-Ai Hospital, Luodong, Yilan1
Pseudoephedrine is a widely used sympathomimetic amine
on patients with rhinorrhea and allergic rhinitis. The vasoconstriction
effect is believed to be principally an on α-adrenergic receptor response. Urinary retention was considered contraindication while use on patients with concomitant prostatic hypertrophy needs precautions. Although not one of the most seen overall side effects, patients suffered from urinary retention or dysuria after taking pseudoephedrine may come to urologists for help. The study aimed to elucidate the impact of pseudephedrine on lower urinary tract symptoms (LUTS) in patients without self-reported voiding dysfunction.
Materials and Methods:
All male patients came to our Otolaryngology OPD for acute or chronic rhinitis was asked by doctors to make sure they are free from voiding dysfunction by self-reported. Then patients with voiding problems or under current medication treatment for LUTS were excluded. Other patients were given medication according to the individual clinical symptoms. Once pseudoephedrine was prescribed, International Prostate Symptom Score (IPSS) questionnaires were filled in by the patients. After treatment with pseudoephedrine for 1 week, a post-medication IPSS questionnaire was filled for follow-up. Total 68 patients complete the survey. Age, IPSS total score, IPSS voiding score, IPSS voiding score, quality of life score were analyzed for correlation.
The average age of total 68 patients was 38.7 year-old (15-71 year-old). The average IPSS total score before and after medication was 4.81 and 6.54 respectively. The average IPSS voiding / storage score before medication were 2.53/2.35 and changed to 3.68/2.87 after medication. Quality of life score based on voiding condition were 1.88 and 2.03 before and after medication. Independent T-test was used to evaluate the predictors for worsen (defined as increased IPSS-T) and stable (defined as equal or decreased IPSS-T) voiding condition. Age, pre-medication IPSS-T and IPSS-V were significant predictors for worsen voiding function after taking pseudoephedrine. Quality of life score based on voiding condition before and after medication showed no significantly difference.
Patients who were self-reported free from voiding dysfunction may still suffer from increased LUTS after pseudoephedrine. Age and pre-medication IPSS-V score could be predictors for the presence of increased LUTS.