研究 STAT3 蛋白質表現與台灣上泌尿道上皮癌之相關性
柯宏龍1,2,3, 陳思翰1,3, 林慧惠2,3, 李威明1,2,3,5, 李經家1,2,3,4,葉信志1,2,3,4, 黃俊農1,2,3, 吳文正1,2,3,5
高雄醫學大學 醫學研究所1 泌尿學科2
Signal transducers and activators of transcription 3 (STAT3) expression and the prognosis in upper urinary tract urothelial carcinoma
Hung-Lung Kea,b,c , , Szu-Han Chena,c, Hui-Hui Linb,c , Wei-Ming Lia,b,c,f ,Ching-Chia Li a,b,c,e, Hsin-Chih Yeha,b,c,d , Chun-Nung Huang a,b,c, Wen-Jeng Wua,b,c,d
aGraduate Institute of Medicine, bDepartment of Urology , College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan cDepartment of Urology, Kaohsiung Medical University Hospital, dDepartment of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, eDepartment of Urology, Kaohsiung Municipal Ta-Tung Hospital, , Kaohsiung Medical University, Kaohsiung, Taiwan fPingtung Hospital , Department of Health, Executive Yuan, Pingtung , Taiwan
Signal transducers and activators of transcription (STATs) play an important role in gene regulation, cell proliferation and differentiation. We aimed to establish the relationship between STAT3 expression and the prognosis of upper tract urothelial carcinoma (UTUC).
Materials and Methods:
This study retrospectively reviewed 100 patients with pathologically confirmed UTUC at Kaohsiung Medical University Hospital. We quantify the expressions of STAT3 in cancer cells by immunohistochemistry method, and determine the clinicopathologic significance between expression of STAT3 and prognostic outcome in patients with UTUC.
High STAT3 expression was detected in 52% of whole UTUC patients. High STAT3 expression was associated with poor recurrence-free (p=0.018) and overall survival (p=0.026). In the advanced cancer (stageT3/T4), STAT3 expression is the only independent prognostic factor for recurrence-free survival (hazard ratio=5.91, p=0.01) and cancer-specific survival (hazard ratio=8.83, p=0.039).
In UTUC, the STAT3 can be a potential prognostic marker for cancer recurrence and survival, especially in the advanced stage.