Functional bladder capacity correlates to severity of symptoms in patients with interstitial cystitis/painful bladder syndrome
Hui-Ying Liu、Yao-Chi Chuang
Division of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine
To investigate the correlation between functional bladder capacity and the pain scale, and clinical symptoms in patients with interstitial cystitis/painful bladder syndrome (IC/PBS).
Materials and Methods:
A retrospective study of 30 patients with symptoms of IC/PBS were included. Functional bladder capacity was detected according to 3-day voiding diary. Bladder hydrodistention were performed under intravenous sedation or general anesthesia. A self-administered questionnaire containing pain and urgency visual analogue scale (VAS), O’Leary-Sant Symptom and Problem Indexes (including Interstitial Cystitis Symptoms Index (ICSI) and Interstitial Cystitis Problem Index (ICPI)) were obtained. The effects of hydrodistension were evaluated by Global Response Assessment (GRA). A two-sample t test was performed to identify the differences of continuous variables between the two groups with functional bladder capacity of > 350ml and ≤ 350ml, and simple logistic regression was applied to assess functional bladder capacity with pain scale, symptom score, age, and bladder capacity in hydrodistention. The p value <0.05 was considered to be statistically significant. Statistical analyses were performed using SPSS 20.0 statistics software (SPSS Inc., Chicago, IL).
The baseline character has no significant difference between two groups( functional bladder capacity of > 350ml and ≤ 350ml) in age, pain and urgency VAS, ICSI, ICPI, or post-voiding residual urine amount. There is a trend of higher pain scale and symptom score as functional bladder capacity decreased. Furthermore, mean urgency in 3-day voiding diary, bladder capacity on hydrodistention, and GRA showed statistically significant difference between two groups.
Functional bladder capacity correlates with pain scale and symptom scores. The group of functional bladder capacity > 350ml has larger bladder capacity in hydrodistention and significantly symptoms improvement after hydrodistension.