愷他命長期低劑量使用者下泌尿道症狀調查報告
楊緒棣1 張美玉2 李高漢3 許汶蒼4 張尚仁1
- 台北慈濟醫院泌尿科 2. 高雄市立小港醫院泌尿科 3. 美醫院泌尿外科 4.衛福部基隆醫院泌尿科
Lower urinary tract symptoms and sexual function in low dose short-term ketamine abusers
Stephen S. Yang1, Mei-Yu Chang2, Kao-Han Lee3, Wen-Chang Hsu3, and Shang-Jen Chang1
1. Division of Urology, Taipei Tzu Chi Hospital 2. Division of Urology, Kaohsiung Municipal Siaogang Hospital 3. Division of Urology, Chi Mei Hospital 4. Division of Urology, Keelung Hospital, Department of Health and welfare
Purpose: “Ketamine once, Diaper forever” is the official slogan of anti-ketamine activity in Taiwan. Contracted bladder with severe lower urinary tract symptoms (LUTS) is well known in high dose long-term ketamine abusers. Herein, we report the prevalence of LUTS in low dose short-term ketamine abusers.
Materials and Methods: Ketamine abusers caught by policemen were invited to answer the structured questionnaires including demographic data, history of drug abuse, international prostate symptoms score (IPSS), interstitial cystitis symptoms and quality index (ICSI and ICPI). In addition, international index of erectile function (IIEF-5), and female sexual function index (FSFI) were answered by men and women, respectively.
Results: Of 3 cities in Taiwan, 335 subjects with a mean age of 27.23±6.37 years were enrolled in 2016. Mean duration of ketamine abuse was 28.2±33.2 months. Dose distribution was 0.1-1.0gm in 147, 1.1-1.9gm in 56, 20-4.9gm in 54 and >=5.0gm in 25 subjects. Mean IPSS, ICSI and ICPI were 3.13±7.46, 1.94±2.45 and 1.51±3.00, respectively. Duration of ketamine abuse was associated with IPSS and ICPI, while not associated with ICSI (figure 1). Dose effects were not observed in the study.
Mean IIEF-5 of 269 men was 22.4. Duration and dose of ketamine abuse was not associated with IIEF-5. Mean FSFI of 57 women was 31.5±22.11. Duration and dose of ketamine abuse was associated not with FSFI.
Conclusions: Most ketamine abusers had no significant LUTS. Duration of ketamine abuse was associated with IPSS, and ICPI. High rate of low IIEF-5 was observed in male ketamine abusers.