1.三軍總醫院 外科部 泌尿科 2.三軍總醫院 放射腫瘤部
To evaluate the risk of erectile dysfunction in inflammatory bowel disease
Chien-Chang Kao, Wen-Yen Huang, Chia-Hung Kao
1.Divisions of Urology, Department of Surgery, Tri-service general hospital, Taiwan 2. Department of radio-oncology, Tri-service general hospital, Taiwan 3. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
To determine whether inflammatory bowel syndrome (IBS) is associated with an increased risk for the subsequent erectile dysfunction (ED).
Materials and Methods:
We identified 1,845 patients who were diagnosed with IBS between 2000 and 2011 from the Taiwan National Health Insurance Research Database (NHIRD) as the study cohort, and randomly extracted the data of 7,380 patients matched by sex, age, and baseline year for the comparison cohort. The follow-up period was terminated after erectile dysfunction development, withdrawal from the national health insurance (NHI) system, or at the end of 2011. Cumulative incidences and hazard ratios (HRs) of ED development were determined.
During the first 12 years of follow-up, the subsequent ED incidence rates in the IBS and comparison cohorts were 2.23 and 1.29 per 10,000 person-years, respectively (adjusted HR, 1.64; 95% CI, 1.07–2.53; p b .0001). Furthermore, relative to the non-IBD cohort without any comorbidity, the IBD patients with any comorbidity were at a much higher risk of erectile dysfunction (adjusted HR=8.93, 95% CI=3.83-20.8) compared to patients with comorbidities alone (adjusted HR=3.35, 95% CI=1.54-7.28) or with IBD alone (adjusted HR=1.78, 95% CI=0.74-4.27)
This study is to investigate the long-term risks of ED in patients with IBD. It demonstrates that the patients with IBD was at a 1.64-fold higher risk of developing ED than non-IBD control group after adjusting age and comorbidities.