雷射流式細胞儀可以有效預估女性非複雜性泌尿道感染的治療效果
陳義昇1, 楊緒棣1 , 楊淳淳2, , 張尚仁1
1台北慈濟醫院外科部泌尿科 2台北慈濟醫院檢驗科
Laser Flow Cytometry UF-1000i is useful in predicting therapeutic outcomes in women with uncomplicated urinary tract infections
Yi-Sheng Chen1, Stephen Shei-Dei Yang1, Chun-Chun Yang2, Shang-Jen Chang1
1 Division of Urology, Taipei Tzu Chi Hospital, New Taipei, Taiwan
2 Division of General Laboratory, Taipei Tzu Chi General Hospital, New Taipei, Taiwan
Purpose: To investigate usefulness of the bacterial diagram generated from the laser flow cytometry of UF-1000i (Sysmex, Kobe, Japan) in treating women with uncomplicated urinary tract infection (uUTI).
Materials and Methods: In 3 years, women aged 20-80 years with symptoms suggestive of uUTI and Urinary Tract Symptoms Assessment questionnaire (UTISA) ≥ 4 were enrolled and cephalexin 500mg 4 times a day for 7 days was given after enrollment. Bacterial count and diagram to differentiate rods or cocci/mixed bacteria were done by UF-1000i. UTISA and urinalysis were performed again on 3rd and 7th treatment day. Clinical improvement is defined as UTISA <4, and laboratory improvement as bacterial count <100/uL on day 7.
Results: Mean age and UTISA-0 of 155 women were 50.19 ±15.43 years and 10.37 ±4.08, respectively. There were 42 women had a bacterial count <100/uL and they were regarded not true UTI. Of 112 women with a bacterial count >≥100/uL 85 were classified as rods and 20 as cocci/mixed. Clinical improvement was observed in 67 (78.8%) and 12 (60.0%) women with rods and cooci/mixed respectively (p=0.087). Laboratory improvement was noted in 68 (80.0%) and 11 (55.0%) women with rods and cooci/mixed respectively (p=0.020).
Conclusions: Bacterial count may help to avoid use of antibiotics in women without UTI. Bacterial diagram may help selection of antibiotics to improve the response rate in women with uUTI.