半胱氨酸蛋白酶-8的基因型在中台灣膀胱癌風險性的貢獻度
廖丞晞1,2,3,4、張文馨2,3、蔡佳紋2,3、吳錫金5、包大靝2,3
1國軍台中總醫院外科部泌尿外科 2中國醫藥大學生物醫學研究所 3Terry Fox癌症研究室 4國防醫學院臨床醫學研究所 5中國醫藥大學附設醫院泌尿外科 6彰化基督教醫院眼科部
The Contribution of Caspase-8 Genotypes in the Urinary Bladder Cancer Risk in mid-Taiwan
Cheng-Hsi Liao1,2,3,4, Hsi-Chin Wu5, Wen-Shin Chang2,3, Chia-Wen Tsai2,3 , and Da-Tian Bau2,3
1Division of Urology, Department of Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.; 2Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan, R.O.C.; 3Terry Fox Cancer Research Laboratory; 4Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, R.O.C.; 5Department of Urology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Purpose:
Rs3824129 is a functional six nucleotide insertion(I)/deletion(D) polymorphism in the promoter region of caspase-8, an essential apoptosis gene. We aimed to examine the association of this polymorphism with the risk of bladder cancer in the Taiwanese population.
Materials and Methods:
Caspase-8 rs3834129 genotypes were determined and their associations with bladder cancer risk were evaluated among 375 patients and 375 controls by the PCR-RFLP methodology. In addition, the interaction of caspase-8 rs3834129 genotypes with personal behaviors and clinic pathological features were examined.
Results:
The frequencies of II, ID and DD genotypes for caspase-8 rs3834129 were non-differentially distributed between the two groups (p for trend=0.7187). Analysis of allelic frequency distribution also indicated that the D variant allele was not associated with a risk of bladder cancer. There was no obvious joint interaction between caspase-8 rs3834129 genotypes and smoking, alcohol consumption, and clinical stage and grade.
Conclusion:
Caspase-8 rs3834129 genotypes play a minor role in the personal susceptibility to bladder cancer in mid-Taiwan.