經尿道前列腺切除術術後使用甲型阻斷劑及膀胱過動症藥物之影響因子
薛丞勛1、李建儀2
1臺中榮民總醫院教學部；2臺中榮民總醫院泌尿外科部
Factors Associated with The Usage of Alpha-blockers and Overactive Bladder Medicines After Transurethral Resection of Prostate
Chen-Hsun Hsueh1, Jian-Ri Li2
1Department of Education, Taichung Veterans General Hospital, Taichung, Taiwan;
2Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan
Purpose: We investigated the factors associated with the usage of alpha-blockers and medicines for overactive bladder (OAB) after transurethral resection of prostate (TURP) in patients with benign prostate hyperplasia (BPH) in Taichung Veterans General Hospital.
Materials and Methods: A total of 250 patients with BPH receiving TURP from January, 2007 to December, 2020 were included. The usage of alpha-blockers and medicines for OAB were analyzed respectively, and was defined as receiving these medicine at least a month after TURP with treatment lasting at least three months. We analyzed factors including age, body mass index, pre-TURP prostate specific antigen value, comorbidities, pre-TURP usage of alpha-blockers, OAB medicines and 5-alpha reductase inhibitors, TURP methods, resected prostate volume ratios, pre-TURP urine flow test results in this study.
Results: There was significant association between chronic kidney disease (CKD) and the usage of alpha-blockers after TURP (odds ratio 1.93, p-value 0.036). Meanwhile, there was significant association between the usage of OAB medicines after TURP with pre-TURP usage of OAB medicines (odds ratio 2.33, p-value 0.046) and resected prostate volume ratio during TURP (odds ratio 0.12, p-value 0.013).
Conclusions: BPH patients with underlying CKD were more likely to require long-term alpha-blockers after TURP. In the meantime, BPH patients who required long-term OAB medicines before TURP and who received lower prostate volume resection ratio were more liable to long-term OAB medicines after TURP.