同時性攝護腺癌與腎細胞癌的臨床意義:5個案例報告

徐明蔚、楊啟瑞、黃志平、陳汶吉

中國醫藥大學附設醫院 泌尿部

Bad-Luck but Good Outcome: The Clinical Implications of Synchronous Prostate Cancer and Renal Cell Carcinoma in 5 Cases

Ming-Wei Hsu, Chi-Rey Yang, Chi-Ping Huang, Wen-Chi Chen

Department of Urology, China Medical University Hospital, Taichung, Taiwan

Purpose

Prostate cancer and renal cell carcinoma are two commonly seen malignancies in the genitourinary tract. However, prostate cancer synchronous with renal cell carcinoma (PC+RCC) is rare, with only few case reports published. Certain genetic and environmental factors are considered to exist but the exact etiology remains elusive. Some believe longevity and strict assessment by the same urologist render the diagnosis of concurrent malignancies possible. Here, we represented 5 cases of synchronous prostate cancer and renal cell carcinoma with good outcomes in a single academic medical center. 

Materials and Methods

From 2012 to 2020, 5 patients diagnosed as synchronous prostate cancer and renal cell carcinoma under management in a single institution were reviewed.

Reports

We reported 5 patients (age range from 56 to 80 years old) of PC+RCC and analyzed their clinical manifestations. One of them had triple primary cancers with initial diagnosis of rectal cancer; one of them was RCC synchronous with PC; three of them were PC synchronous with RCC. iPSA ranged from 4.28 to 27.47 ng/dl. The diagnosis of second primary cancer seemed early as both cancers belong to the same GU tract malignancies. RCC were treated with radical or partial nephrectomy and prostate cancer were managed with radical prostatectomy or hormonal therapy plus radiotherapy. Among them, 2 are chromophobe renal cell carcinoma and 3 are clear cell renal cell carcinoma. All patients survive till now (range from 1 year to 10 years). 

Conclusion

There is bad luck with good outcomes on these patients because they were diagnosed and treated by urologists in a single center. Further analysis regarding the epidemiological and prognostic factors in this rare condition will be conducted.