(PD3-6) The association of interleukon-10 promoter genotypes to taiwanese renal cell carcinoma susceptibility
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  • 2015-11-30,
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介白素-10促進因子基因型與台灣腎臟細胞癌敏感性的關聯
廖丞晞1,2,3,4 張文馨2,3 胡佩欣6 吳錫金5 蔡佳紋2,3 許欽木2,3 稅皓靄4 包大靝2,3,4
1國軍台中總醫院泌尿外科; 2中國醫藥大學臨床醫學研究所; 3Terry Fox癌症研究室;
4國防醫學院臨床醫學研究所; 5中國醫藥大學附設醫院泌尿外科; 6彰化基督教醫院眼科部
The association of interleukon-10 promoter genotypes to taiwanese renal cell carcinoma susceptibility  
Cheng-Hsi Liao1,2,3,4 , Wen-Shin Chang2,3 ,Pei-Shin Hu6, Hsi-Chin Wu5, Chia-Wen Tsai2,3, Chin-Mu Hsu2,3, Hao-Ai Shui4 ,and Da-Tian Bau1,2
1 Department of Urology, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.;
2 Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.;
3 Terry Fox Cancer Research Laboratory;
4 Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, R.O.C.;
5 Department of Urology, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
6 Department of Ophthalmology, Changhua Christian hospital, Changhua, Taiwan, R.O.C.
 
Purpose:
Renal cell carcinoma (RCC) accounts for about 3% of all cancer-related mortalities worldwide and the risk factors for the development of RCC have not yet been fully elucidated. Mounting proteomic evidence suggests that inflammatory process plays a role in RCC etiology, and interleukin-10 (IL-10) is an important immunosuppressive cytokine. However, little is known about the contribution of IL-10 genotypes to RCC. The study aimed at evaluating the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of RCC in Taiwan.
Materials and Methods:
Associations of the three IL-10 polymorphic genotypes with the risk of RCC were examined among 92 RCC patients and 580 age- and gender-matched cancer-free controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.
Results:
The pilot results showed that the percentages of TT and TC for IL-10 T-819C genotypes were significantly higher in the RCC patient group than those in the healthy control group. The CC genotype carriers were of lower risk for RCC (odds ratio=0.45, 95% confidence interval=0.23-0.72, p=0.0033). There is no difference in the distribution of A-1082G or A-592C genotype between the RCC and control groups.
Conclusions:
In summary, the CC genotype of IL-10 T-819C genotype may have a protective effect on RCC risk in Taiwan. Further investigation with larger sample size in addition to genotype-phenotype correlation and intracellular mechanisms are our future work.
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    2015-11-30 10:47:00
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