#0607

Videourodynamic predictive factors of urological complications in patients with chronic spinal cord injury and detrusor sphincter dyssynergia

C. Weng¹, S. Chen², H. Kuo²

¹Medical Administration Office, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Medical Education, Hualien, Taiwan
²Buddhist Tzu Chi General Hospital, Tzu Chi Medical Foundation, and Tzu Chi University, Department of Urology, Hualien, Taiwan

Introduction:

Patients with spinal cord injury (SCI) often develop neurogenic lower urinary tract dysfunction (NLUTD), with detrusor sphincter dyssynergia (DSD) being a prevalent and clinically significant condition. The severity of DSD is classified into three grades, with higher grades may associated with increased risk of urological complications. However, few studies have systematically compared these complications across different DSD grades.

Material and methods:

We conducted a retrospective cohort study of 543 SCI patients diagnosed with neurogenic detrusor overactivity (NDO) and DSD using video urodynamic study (VUDS) and electromyography (EMG) evaluations. Patients were categorized into non-DSD, DSD grade 1, DSD grade 2, and DSD grade 3 groups. (Figure 1) The primary outcome was the incidence of urological complications including recurrent urinary tract infection (rUTI), renal stone, bladder stone, vesicoureteral reflux (VUR), hydronephrosis, autonomic dysreflexia (AD) among different groups. The secondary outcome uses logistic regression models to assess the association between different DSD grades, bladder management strategies, VUDS parameters and the occurrence of complications.

Results:

Higher DSD grades were significantly associated with an increased risk of rUTI and AD. (Table 1 and 2) Spontaneous voiding was linked to a lower risk of both complications, whereas CIC was associated with a higher incidence of rUTI, and IDC was linked to an increased risk of AD. However, VUDS parameters were not significantly correlated with the occurrence of complications. (Table 3) Subgroup analyses further revealed that CIC was associated with a higher risk of hydronephrosis in patients with DSD grade 1, while IDC was linked to an increased risk of AD in patients with DSD grade 3.