#1484

Systematic Review and Meta-analysis of the Association Between CONUT Score and High-Grade Postoperative Complications in Bladder Cancer Patients Undergoing Radical Cystectomy

H. Huang¹, L. Lai², P. Liao³, L. Chen³, L. Chiu³, R. Cheng³, H. Hsu⁴, M. Tsai⁵, P. Huang⁶

¹Chi Mei Medical Center, Department of Medical Education, Tainan, Taiwan
²Hungkuang University, Department of Nursing, Taichung, Taiwan
³Yuanli Lee Hospital, Department of Nursing, Miaoli, Taiwan
⁴Dajia Lee Hospital, Department of Nursing, Taichung, Taiwan
⁵Centers for Disease Control, Ministry of Health and Welfare, Quarantine Department, Taichung, Taiwan
⁶Dajia Lee Hospital, Department of urology, Taichung, Taiwan

Introduction:

Bladder cancer is a common condition in the field of urology. Numerous studies have identified the Controlling Nutritional Status (CONUT) score as a valuable tool for predicting tumor-related outcomes. This study aims to investigate whether patients with bladder cancer who exhibit higher CONUT scores prior to undergoing radical cystectomy are at increased risk of developing severe postoperative complications, defined as Clavien-Dindo Grade ≥ 3. The findings may offer important insights for guiding clinical decision-making.

Material and methods:

Clinical questions were formulated using evidence-based principles and the PICO framework. Relevant keywords and MeSH terms were applied, and Boolean logic was used to conduct comprehensive searches in databases including PubMed, the Cochrane Library, and the Airiti Library. An initial search yielded 8 articles. After removing duplicates and studies that did not meet the inclusion criteria or align with the PICO focus, 2 articles were selected for final analysis. The quality of the included non-randomized studies was assessed using the ROBINS-I (Risk Of Bias In Non-randomized Studies - of Interventions).

Results:

A total of 462 patients were included across the two selected studies. Meta-analysis was performed using Review Manager software (version 5.4). The results demonstrated that patients with higher CONUT scores had a significantly increased risk of developing high-grade postoperative complications compared to those with lower scores. The calculated risk ratio (RR) was 2.27 (95% confidence interval: 1.58–3.27, p < 0.01, I² = 78%).