#1186
Analysis of Time to Prostate-specific antigen (PSA) Nadir After Radical Prostatectomy In Taiwan
W. Tu1, S. Chung1, S. Hung1, C. Tsai1, S. Yii1, C. Chang1, P. Cheng1
1Far Eastern Memorial Hospital, Division of Urology, Department of Surgery, New Taipei City, Taiwan
Introduction:
Radical prostatectomy (RP) is one of the main treatment options for localized prostate cancer (PCa), aiming to achieve complete tumor removal and cancer control. PSA kinetics following RP is of the great interests and defenitively related to oncological outcomes. Prior studies from Western population have reported that PSA levels typically become undetectable within 6 to 10 weeks after surgery. However, data concerning the timing of nadir PSA following RP in Asian populations remain scarce. Therefore, the purpose of this study is to investigate time to PSA nadir in patients after RP and potential factors associated with the time span
Material and methods:
We retrospectively analyzed patients who underwent RP at Far Eastern Memorial Hospital between 2017 and 2024. Patients who lost to follow-up, experienced PSA persistence, received immediate initiation of hormone therapy postoperatively, and who had irregular PSA follow-up were excluded from the study. The patient demographics such as total prostate volume (TPV)( <40 vs. >40 ml), initial PSA (<20 vs. >20 ng/ml), clinical tumor stage (cT1+cT2 vs. cT3), pathology tumor stage (pT1+pT2 vs. pT3), and Gleason score (ISUP Grade Group 1-3 vs. 4-5) were reviewed. Student's t-test was used to compare the time to PSA nadir among different subgroups. Statistical analysis was performed with IBM SPSS version 27
Results:
A total of 101 patients were included in the initial dataset, and finally 74 patients were selected for analysis. The mean age was 66.19±6.73 years. Patient has median TPV 33.9 ml and initial PSA (IPSA) 9.7 ng/ml. The median time to PSA nadir was 77.0 days. There were no statistically significant differences in time to PSA nadir, regarding to different subgroups of TPV, IPSA, clinical stage, pathology stage, and ISUP Grade Group. (Figure)The observed median time to nadir aligns with previous reports from non-Asian cohorts, indicating that our local population may follow similar PSA dynamics following RP. Our current study is limited by its small sample size, and larger multi-center analyses are warranted to validate these findings