#0376
Exploring the causal relationship between kidney volume and renal disease and renal function: a bidirectional two-sample Mendelian randomization study
J. Wang1, X. Ma1
1The Third Medical Center of Chinese PLA General Hospital, Department of Urology, Beijing, China
Introduction:
Kidney volume is an important body parameter, but its bidirectional causal relationship with renal function, acute kidney injury (AKI), and chronic kidney disease (CKD) remains unclear.
Material and methods:
We investigated causal associations between kidney volume and renal outcomes (renal function, AKI, CKD) using two-sample Mendelian randomization. Data were sourced from genome-wide association studies in the IEU OpenGWAS Project, incorporating renal function metrics including eGFR (creatinine/cystatin) and blood urea nitrogen. The inverse variance weighting (IVW) method was applied, with results presented as odds ratios (ORs) and 95% confidence intervals (CIs).
Results:
MR analysis revealed that a larger kidney volume was associated with a smaller possibility of AKI (OR=0.410; 95% CI: 0.239, 0.703; P=0.001) and a higher eGFRcrea (OR=1.095; 95% CI: 1.048, 1.143; P<0.001). Reversely, CKD (OR=0.824; 95% CI: 0.767, 0.885; P<0.001), eGFRcrea (OR=8.683; 95% CI: 5.145, 14.654; P<0.001) and BUN (OR=0.781; 95% CI: 0.713, 0.854; P<0.001) have been demonstrated to induce alterations in kidney volume, with a notable correlation. The results of the sensitivity analysis indicate that these findings are reliable.