#1237

A Rare Case of Neurilemmoma at the Glans Penis: Comprehensive Clinical and Radiological Evaluation, Surgical Management, and Long-term Follow-up

S. Sankhala¹, S. Raina¹

¹Jaslok hospital and research centre, Urology, Mumbai, India

Introduction:

Schwannomas, or neurilemmomas, are rare peripheral nerve sheath tumors, with penile involvement being exceptionally uncommon. Schwannomas of the external genitalia, especially the glans penis, are rarely reported. They are typically benign, slow-growing, and often associated with neurofibromatosis type 2 (NF2) gene mutations.

Material and methods:

A 33-year-old male presented with a painless, slow-growing mass on the dorsal glans penis. Clinical examination revealed a well-circumscribed, mobile, nodular lesion with no signs of inflammation. Imaging with penile ultrasonography and contrast-enhanced multiplanar MRI confirmed a hypoechoic, vascular lesion distinct from the corpus cavernosum. Intraoperative frozen section analysis showed no malignant cells. Complete surgical excision was performed under general anesthesia.

Results:

Histopathological examination revealed a well-circumscribed spindle cell tumor with nuclear palisading and myxoid changes, consistent with schwannoma. Immunohistochemical staining showed strong and diffuse S-100 positivity, confirming the diagnosis. Postoperatively, erectile function was normal at 3 months, with no recurrence or progression over a follow-up of 4.5 years. Complete excision provided definitive treatment without oncological compromise.