#1198

The Deflux Injection Reduced the Incidence of Urinary Tract Infections in Children with Vesicoureteral Reflux

S. Chen¹, T. Wang¹, M. Yu^2,3, K. Lin⁴, C. Lin⁴, H. Wang⁴, Y. Lin⁴, P. Pan⁴

¹Linkou Chang Gung Memorial Hospital, Division of General Urology and Renal Transplantation, Department of Surgery,, Taoyuan, Taiwan
²Lin-Kou Chang Gung Memorial Hospital, Pediatric Nephrology, Taoyuan, Taiwan
³Chang Gung University, College of Medicine, Taoyuan, Taiwan
⁴Lin-Kou Chang Gung Memorial Hospital, Division of General Urology and Renal Transplantation, Department of Surgery,, Taoyuan, Taiwan

Introduction:

The aim of this study is to report the experience of a single injection of Dextranomer/hyaluronic acid copolymer (Deflux) and assess its effectiveness in reducing the incidence of urinary tract infections (UTIs) in children with vesicoureteral reflux (VUR).

Material and methods:

The medical records of 31 patients with VUR, who were presented between 2019 and 2023, were retrospectively reviewed. Data collected included: demographics, the number of preoperative and postoperative UTIs, a radiological grade of VUR on a voiding cystourethrogram (VCUG) 12 months after the procedure. Patients continued on oral antibiotics until urine culture was negative or no reflux was demonstrated on VCUG.

Results:

The mean age of 31 patients was 24.8 months, and 58% were girls. 17 patients have bilateral VUR. Of the 48 ureters treated, 6 had Grade II, 23 Grade III, 13 Grade IV, and 6 Grade V. The overall radiological success rate of the procedure was 77% after the single injection. The success rate per grade was: 83% for Grade II, 87% for Grade III, 69% for Grade IV, and 50% for Grade V. The mean follow-up was 3.23±1.6 years. The overall clinical success rate of the procedure was 90%. Three (9.7%) patients had febrile UTIs after the procedure, compared to 21(68%) before the procedure.