#0244

Comparing TURP and HoLEP for Benign Prostatic Hyperplasia Treatment: A Meta-Analysis Using Common Data Model Data from Korean Hospitals

S. Choi¹, Y. Lee², C. Lim², K. Mim³, J. Tae¹, I. Chang¹, T. Kim¹, S. Myung¹

¹Chung-Ang University, Urology, Seoul, Korea (Republic of)
²Chung-Ang University, Statistics & Data Science, Seoul, Korea (Republic of)
³Chung-Ang University Hospital, Urology, Seoul, Korea (Republic of)

Introduction:

We tried to evaluate and compare the efficacy and safety of Transurethral Resection of the Prostate (TURP) and Holmium Laser Enucleation of the Prostate (HoLEP) for treating benign prostatic hyperplasia (BPH) using standardized multicenter data.

Material and methods:

We retrospectively collected data from six Korean hospitals via the Common Data Model (CDM) and performed a meta-analysis. Patients were categorized into TURP (control) and HoLEP (experimental) groups, and risk ratios (RR) were calculated to compare postoperative outcomes and complications. Sensitivity analyses were conducted by sequentially excluding each hospital’s data to assess the robustness of the findings.

Results:

HoLEP was associated with significantly lower reoperation and transfusion rates, as well as reduced postoperative use of medications (including alpha-blockers and 5-ARIs), compared to TURP. Conversely, beta-3 agonist usage was notably higher in the HoLEP group, suggesting the need for further investigation in this area. Sensitivity analyses confirmed that the overall results remained robust across individual hospital exclusions.