睪丸癌與淋巴癌病人在冷凍精子的品質比較
高銘鴻1,4、彭元宏3、張宏江1,2
臺大醫院泌尿部1、臺大醫院新竹分院泌尿科2、天晟醫院泌尿科3、恩主公醫院泌尿科4
The comparison of sperm quality of cryopreservation between patients with testicular cancer and lymphoma
Ming-Hong Kao1,4、Yuan-Hung Pong3、 Hong-Chiang Chang1,2
Department of Urology, National Taiwan University Hospital1; Department of Urology, Taipei, Taiwan, National Taiwan University hospital Hsin-Chu Branch2; Hsin-Chu, Taiwan, Department of Urology, Ten-Chan Hospital3; Taoyuan, Taiwan , En-Chu Kong Hospital4, New Taipei city, Taiwan
Purpose: To compare sperm quality of cryo-preservation between testicular cancer and lymphoma
Materials and Methods: We retrospectively collected patients with testicular cancer and lymphoma receiving sperm cryo-preservation from 2000 to 2015 in our tertiary center. We recorded the sperm concentration, motility, and normal percentage. Success sperm cryopreservation was ejaculated volume > 1.5 mL, sperm concentration > 5 × 106 sperm/mL, and sperm motility > 10%.
Results: The successful cryo-preservation rate of lymphoma is 73.6% (39 of 53 patients) and testicular cancer is 61% (36 of 59 patients). In comparison of successful cryopreservation between lymphoma and testicular cancer, there is no statistical difference of age( 25 versus 25 years old, p= 0.467) and sperm concentration (30 versus 20 millon sperm/mL, p= 0.058). The lymphoma patients has higher normal sperm percentage(32% versus 25%, p= 0.011) and higher normal motility percentage (36% versus 23.5%). In cryo-failure group, 9 of 14 lymphoma patient received chemotherapy before cryopreservation and no testicular cancer patient received chemotherapy before cryo-preservation. In patient of lymphoma with previous chemotherapy, the successful group has fewer days from initial chemotherapy. (16 versus 74.5 days).
Conclusions: The success rate of cryo-preservation of lymphoma was higher than testicular cancer. Even in success cryo patient, the sperm quality of patients with
lymphoma is better than testicular cancer.