RON在上泌尿道泌尿上皮癌的預後意義
鄭嘉緯1、蔡育賢1、周詠欽2、蔡欣孜1、楊文宏1、周楠華3、蔡宗欣1
1國立成功大學醫學院附設醫院泌尿部、3病理部；2嘉義基督教醫院外科部泌尿科
Prognostic Relevance of RON Expression on Upper Tract Urothelial Carcinoma
Chia-Wei Cheng1, Yuh-Shyan Tsai1, Yeong-Chin Jou2, Hsin-Tzu Tsai1, Wen-Horng Yang1, Nan-Hua Chow3, and Tzong-Shin Tzai1
Department of Urology1 and Pathology3, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Department of Urology2, Chia-Yi Christian Hospital, Chia-Yi, Taiwan
Purpose: The oncogenic tyrosine kinase RON (recepteur d’origine Nantais) is involved in human bladder urothelial carcinogenesis and can cross-talk with epidermal growth factor receptor (EGFR) during nuclear translocation as a transcriptional factor. Despite this, little is known whether RON expression can impact the survival in patients with upper tract urothelial carcinoma (UTUC). The aim of the study is to investigate the frequency and clinicopathologic correlates of RON receptor expression in UTUC patients.
Materials and Methods: Immunohistochemical staining for RON, EGFR, and HER2 were done with serial sections from archival specimens of 125 patients who underwent nephroureterectomy plus bladder cuff resection (median follow-up 50 months, range 1 to 177). The correlates between RON receptor expression and overall survival were analyzed by Kaplan-Meier plots, with the log-rank test and Cox proportional hazards model.
Results: RON, EGFR, and HER2 expression was present in 45 of 125 (36.0%), 17 of 125 (13.6%), and 13 of 94 (13.8%) tumors, respectively. Among 45 RON (+) tumors, 8 (17.7 %) and 5 (11.1 %) had EGFR and HER2 co-expression, respectively. Overall, RON expression can predict with poorer disease-specific overall survival (p = 0.0051, HR, 2.36, 95 CI%, 1.33-4.92). Neither co-expressed with HER2 (p = 0.285, HR, 1.85, 95 CI%, 0.46-10.5) nor with EGFR (p = 0.900, HR, 1.06, 95 CI%, 0.36-3.13), the prognostic values did not reach any statistical significance due to small number of sub-group patients.
Conclusions: RON expression predicts for disease-specific overall survival in UTUC patients.