在台灣介白素-10與腎臟細胞癌的專一關聯性
廖丞晞1,2,3*、張文馨1,2*、蔡佳紋2、吳錫金5、胡佩欣6、稅皓靄4、包大靝1,2
1中國醫藥大學臨床醫學研究所; 2Terry Fox癌症研究室; 3國軍台中總醫院泌尿外科;
4國防醫學院臨床醫學研究所; 5中國醫藥大學附設醫院泌尿外科; 6彰化基督教醫院眼科部
SIGNIFICANT ASSOSCIATION OF INTERLEUKIN-10 GENOTYPES WITH RENAL CELL CARCINOMA IN TAIWAN
Cheng-Hsi Liao1,2,3*, Wen-Shin Chang1,2*, Chia-Wen Tsai2, Hsi-Chin Wu5, Pei-Shin Hu6, Hao-Ai Shui4 and Da-Tian Bau1,2
1 Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.;
2 Terry Fox Cancer Research Laboratory and 5 Department of Urology, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
3 Department of Urology, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.;
4 Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, R.O.C.;
6 Department of Ophthalmology, Changhua Christian hospital, Changhua, Taiwan, R.O.C.
* These Authors contribute equally to this work
Purpose: Renal cell carcinoma (RCC) accounts for about 3% of all cancer-related mortalities worldwide and the risk factors for the development of RCC have not yet been fully elucidated. Mounting proteomic evidence suggests that inflammatory process plays a role in RCC etiology, and interleukin-10 (IL-10) is an important immunosuppressive cytokine. However, little is known about the contribution of IL-10 genotypes to RCC. The study aimed at evaluating the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of RCC in Taiwan.
Materials and Methods: Associations of the three IL-10 polymorphic genotypes with the risk of RCC were examined among 92 RCC patients and 580 age- and gender-matched cancer-free controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.
Results: The pilot results showed that the percentages of TT and TC for IL-10 T-819C genotypes were significantly higher in the RCC patient group than those in the healthy control group. The CC genotype carriers were of lower risk for RCC (odds ratio=0.45, 95% confidence interval=0.23-0.72, p=0.0033). There is no difference in the distribution of A-1082G or A-592C genotype between the RCC and control groups.
Conclusions: In summary, the CC genotype of IL-10 T-819C genotype may have a protective effect on RCC risk in Taiwan. Further investigation with larger sample size in addition to genotype-phenotype correlation and intracellular mechanisms are our future work.