攝護腺肥大病人對於原先甲型腎上腺阻斷劑不滿意時改以處方Silodosin之臨床症狀改善探討
翁涵育 、 歐建慧
國立成功大學醫學院附設醫院泌尿部
Subjective symptom improvement of silodosin treatment for BPH patients with unsatisfactory response to initial ɑ1 blocker
Han-Yu Weng, Chien-Hui Ou
Department of Urology, Medical College and Hospital, National Cheng-Kung University, Tainan, Taiwan.
Purpose: To evaluate subjective symptoms improvement of Silodosin treatment for BPH patients with unsatisfactory response to initial ɑ1 blocker.
Material s and Methods: 50 patients diagnosed with BPH and reported with unsatisfactory response to initial ɑ1 blocker were included in this study. IPSS were recorded before and after administration of 4 weeks of Silodosin. No drug withdrawal period was provided when switching the drug. We evaluate subjective improvement of Silodosin treatment according to the International Prostate Symptom Score.
Results: 28 patients (56 %) had subjective improvement according to the International Prostate Symptom Score total score but 22 patients failed to have symptoms improvement. Comparison of symptoms revealed that Silodosin showed significant effect on nocturia. The most frequent adverse drug reaction was ejaculatory disorder with Silodosin.
Conclusions: Silodosin exhibits some efficacy in improving subjective symptoms especially in nocturia for BPH patients with unsatisfactory response to initial ɑ1 blocker