相繼器官衰竭評估分數為輸尿管鏡碎石手術前是否需執行預防術後敗血症之經皮穿腎引流的評估利器
楊有容、賴俊佑、王又德、蕭博任、陳汶吉、吳錫金、張兆祥、黃志平
中國醫藥大學附設醫院 泌尿部
SOFA (Sequential Organ Failure Assessment) score is a valuable tool to evaluate for preoperative percutaneous nephrostomy (PCN) insertion before ureteroscopic lithotripsy (URSL) for prevention postoperative sepsis
You-rong Yang, Chun-yo Laih, Yu-De Wang, Po-Jen Hsiao, Wen-Chi Chen, Hsi-Chin Wu, Chao-Hsiang Chang,Chi-ping Huang
Department of Urology,China Medical University Hospital, Taichung, Taiwan
 
Purpose:
  Ureteroscopy(URS) can now be used for most ureteral stone removals nowaday. However, infection is still the most common complication. Preoperative PCN insertion for kidney drainage before URSL is a good practice to decrease postoperative sepsis rate. Sequential Organ Failure Assessment (SOFA) scores have been advocated to evaluate sepsis recently. The aim of this study is to use SOFA scores to retrospectively evaluate whether preoperative PCN insertion before URSL prevents postoperative sepsis.
Materials and Methods:
  We conducted a retrospective review of all URSL procedures performed at China Medical University Hospital from September 1st 2017 to December 31st 2019. The definition of sepsis is based on the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) published February 23rd 2016 by the Journal of the American Medical Association (JAMA). We collected and analyzed the data between postoperative sepsis and non-sepsis patients which included clinical characteristics, preoperative SOFA score, surgical outcomes, multivariate analysis of affecting factors for postoperative sepsis, and ROC curve of preoperative PCN insertion and postoperative sepsis for patients with high SOFA scores.
Results:
  A total of 830 patients underwent URSL during the 28 month period. Thirty-two (3.9%) patients suffered from postoperative sepsis. Multivariate analysis of affecting factors for postoperative sepsis showed significant difference in age, proximal ureteral stone, severe hydronephrosis, and high preoperative SOFA score. Fifty-eight (7.0%) patients scored above 3 points for SOFA preoperatively. Among these patients, 26 patients (45.8%) got postoperative sepsis, and 32 patients (55.2%) were free of postoperative sepsis. Among these 32 patients, 22 (68.8%) patients had preoperative PCN insertion and were free of postoperative sepsis. Conversely, among these 26 patients, 22 (84.6%) patients did not have preoperative PCN insertion and contracted sepsis postoperatively. The P-value was 0.008, and the odds ratio was 12.1. The area under curve (AUC) was 0.767 (with maximal Youden’s index: 0.533).
Conclusion:
  This study showed the ability of preoperative SOFA scores to predict the post-URSL sepsis rate. By using this convenient and effective tool, patients who are most likely to suffer from post-URSL sepsis can be efficiently identified. Further preventive strategy such as percutaneous nephrostomy (PCN) can be performed before URSL to achieve the better URSL surgical outcomes.
    位置
    資料夾名稱
    摘要
    發表人
    TUA秘書處
    單位
    台灣泌尿科醫學會
    建立
    2020-12-24 14:49:02
    最近修訂
    2020-12-24 14:52:51
    瀏覽
    144
    1. 1.
      Podium 01
    2. 2.
      Podium 02
    3. 3.
      Podium 03
    4. 4.
      Moderated Poster 01
    5. 5.
      Moderated Poster 02
    6. 6.
      Moderated Poster 03
    7. 7.
      Non-Discussion Poster