高雄市立小港醫院 泌尿科1；高雄醫學大學附設中和紀念醫院 泌尿科2；高雄市立大同醫院 泌尿科3
Herpes Simplex Virus and Subsequent Risk of Prostate Cancer: A Cohort Study in Taiwan
Yao-Hsuan Tsao1, Chun-Kai Chang2, Jiun-Hung Geng1, Yung-Shun Juan3
Divisions of Urology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan 1
Divisions of Urology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan2
Divisions of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan3
Purpose: We investigated whether herpes simplex virus (HSV) is associated with an increased risk of developing prostate cancer (PCa), in a cohort study in Taiwan.
Materials and Methods: We identified 30752 men (age>=20 y/o ) diagnosed with prostate cancer (23064 without HSV infected, and 7688 with HSV infected) between 2000 and 2007, from the Taiwan Longitudinal Health Insurance Database 2000. Cox's proportional hazard regression analysis was performed to estimate the effect of HSV on the PCa risk.
Results: The risk of developing PCa was significantly higher in the HSV infected cohort (adjusted HR =1.53, 95% CI = 1.29-1.81) than in the group without HSV infected. Further analyses indicated that patients with STDs of other pathogens had no significantly greater risk of developing PCa.
Conclusions: We found that sexually transmitted diseases may play an etiological role in the development of PCa in Taiwanese men, particularly in those with HSV infected. Further studies are warranted on the association between HSV and PCa in other countries. particularly where the prevalence of PCa is high.