坦索羅新對泌尿道結石病人的效用
黃淳邦、賴韋宏、周詠欽、沈正煌、鄭明進、林昌德、陳丕哲
嘉義基督教醫院 外科部 泌尿科
The Effect of Tamsulosin in Patients with Urolithiasis
Chun-Pang Huang, Wei-Hong Lai, Yeong-Chin Jou, Cheng-Huang Shen, Ming-Chin Cheng, Chang-Te Lin, Pi-Che Chen
Division of Urology, Department of surgery of Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan
Purpose: Several studies investigate the effect of tamsulosin in patients with urolithiasis, but the results remain not consistent. Our goal is to evaluate the efficacy of tamsulosin as a medical expulsive therapy of urolithiasis.
Materials and Methods: We searched PubMed, EMBASE, and the Cochrane Library up to December 2017. All randomized controlled trials were identified in which patients were randomized to receive either tamsulosin or standard therapy with/without placebo for urolithiasis. Eighteen articles from 148 references related to tamsulosin in patients with urolithiasis were reviewed and there were 5 papers fit for analyses. The estimates included the odds ratio (OR), mean difference and 95% confidence intervals (CI) from urolithiasis explusive rate and expulsive time.
Results: The pooled results showed that tamsulosin has higher stone expulsive rate (OR, 2.01; 95% CI, [1.45, 2.77]; p <0.0001). Also, the pooled expulsive time demonstrated that tamsulosin also has significant better effect in urolithiasis patients (MD, -4.17; 95% CI, [-4.37,-3.97]; p <0.00001).
Conclusions: The relevant studies existed heterogeneous and were limited. Tamsulosin has been found to increase and hasten stone expulsion rates and time. Our analysis suggests that tamsulosin plays a role in patients with urolithiasis.