研究USP2表現與台灣上泌尿道上皮癌之相關性
柯宏龍1,3,7、李怡琛1,2、李威明1,3,9、徐偉齊1,3、林慧惠1,3、詹政豪1,3,7、張玲麗1,4、李香瑩1,8、李經家3,7、葉信志3,8、吳文正1,3,7、黃阿梅5,6*
高雄醫學大學 醫學院醫學研究所1；高雄醫學大學 醫學院醫學研究所 解剖學科2，泌尿學科3，微生物與免疫學科4，生物化學科5；高雄醫學大學 臨床醫學研究所6；高雄醫學大學附設醫院泌尿科7，大同醫院泌尿科8；衛生福利部屏東醫院泌尿科9
Prognostic Value of USP2 Overexpression in Upper Tract Urothelial Carcinomas in Taiwan.
Hung-Lung Ke 1,3,7, Yi-Chen Lee 1,2, Wei-Ming Li 1,3,9, Wei-Chi Hsu 1,3, Hui-Hui Lin 1,7, Jhen-Hao Jhan1,3,7, Lin-Li Chang 1,4, Hsiang-Ying Lee1,8, Ching-Chia Li3, 7, Hsin-Chih Yeh3,8 , Wen-Jeng Wu 1,3,7, A-Mei Huang* 5,6
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan1 ; Department of Anatomy2, Urology3, Microbiology4, and Biochemistry5 School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan6 ; Department of Urology7, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Urology, Kaohsiung Municipal Ta-Tung Hospital , Kaohsiung Medical University, Kaohsiung, Taiwan8; Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung, Taiwan9.
Purpose:: USP2 regulates cell growth or death and involves in the pathogenesis of various diseases, including malignant tumors. However, the function of USP2 in upper tract urothelial carcinoma (UTUC) has not been investigated. This study evaluates the clinical significance of USP2 expression in upper tract urothelial carcinoma (UTUC).
Materials and methods: One-hundred and ten cases of UTUC were included in this study and USP2 expression was evaluated by immunohistochemistry and the association of USP2 expression with clinicopathological variables was analyzed.
Results: High USP2 expression was found in 48 (43.6%) of the cancer specimens. High USP2 expression in UTUC tissues was significantly associated with patients who had tumor stage (p = 0.001), tumor grade (p = 0.033), distant metastasis (p = 0.001) and tumor recurrence (p = 0.008 ). USP2 expression did not correlate with bladder recurrence-free (P = 0.661) or extra-bladder recurrence-free (P = 0.787) survival, but high USP2 expression was a significant predictor for cancer-specific survival (P = 0.014).
Conclusion: Our findings indicated that higher USP2 expression is a potential biomarker to predict patient survival. Further study is necessary to investigate the role of USP2 in the carcinogenesis of upper urinary tract UC.