針灸與威而鋼併用對威而鋼藥物動學及大鼠陰莖血流之影響
黃建榮1、薛又仁1、蔡東湖2、葉桂鶯3、邱文祥1
1台北市立聯合醫院仁愛院區泌尿科, 國立陽明大學醫學院傳醫所
2國立聯合大學、3弘光科技大學物理治療學系
Investigation of interactive activity of electro-acupuncture on pharmacokinetics of sildenafil and their synergistic effect on penile blood flow in rats
Andy C. Huang1, Thomas Y. Hsueh1, Tung-Hu Tsai2, Kuei-Ying Yeh3, Allen W. Chiu1
1 Department of Urology, Department of Surgery, Taipei City Hospital & Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
2Department of Chemical Engineering, National United University, Miaoli, Taiwan
3Department of Physical Therapy, College of Medicine and Health Care, HungKuang University
Purpose: Erectile dysfunction (ED) is a disorder found in males throughout the world, which
negatively affects relationships with partners with advancing age. Hence, in this study, we tested a
combined novel treatment of electro-acupuncture (EA) and sildenafil citrate against ED. In addition
to EA therapy, the sildenafil citrate, a phosphodiesterase 5 inhibitor, is a widely recognized drug
that has achieved considerable success in the treatment of ED. However, the combined effect of both the EA and sildenafil has not yet been investigated. Hence, we aimed to examine the effect of EA on the pharmacokinetics and pharmacodynamics of sildenafil in rat plasma.
Materials and Methods: The pharmacokinetic parameters were determined using ultra performance liquid chromatography (UPLC) after EA and sildenafil administration (10 mg/Kg). Following this, the pharmacodynamics was studied via blood flow pattern using developing doppler images of the lower body and penis.
Results: The pharmacokinetic studies demonstrated that sildenafil significantly increases by administration of low-frequency EA. Further, the pharmacodynamic studies using Doppler imaging revealed an elevated blood flow in rat penis compared with lower body during combined treatment of sildenafil and low-frequency EA.
Conclusions: In our study, the pharmacokinetic results demonstrated that low-frequency EA might elevate sildenafil (10 mg/kg, i.v.) concentration in rat plasma, while pharmacodynamic investigation revealed that combined treatment of sildenafil and low-frequency EA enhanced rats’ penile circulation. Therefore, we inferred that the combined therapy of sildenafil and low-frequency EA might be a good candidate for the treatment of ED.