高血脂女性病人長期使用statins下降罹患膀胱癌之風險: 全人口資料庫研究
林毓庭、石宏仁、李良明、溫玉清、林克勳、林雍偉、蕭志豪、許軒豪、黃俊仁1
1台北市立萬芳醫院 泌尿科；2台北市立萬芳醫院 麻醉科
Long-term statins use reduces risk of bladder cancer in hyperlipidemia women: A population-based study
Yu-Ting Lin, Hung-Jen Shih, Liang-Ming Lee, Yu-Ching Wen, Ke-Hsun Lin, Yung-Wei Lin, Chi-Hao Hsiao, Chun-Jen Huang1
Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
1Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Purpose:
Data regarding the association between statins use and cancer risk in hyperlipidemia patients are heterogeneous. Emerging evidence suggests that the association of hyperlipidemia with the risks of some types of cancer differs between men and women. We conducted this nationwide longitudinal cohort study to evaluate the association between statins use and the risk of bladder cancer in men and women with hyperlipidemia.
Materials and Methods:
Data was retrieved from Taiwan National Health Insurance Database between January, 2000 and December, 2012. Newly diagnosed hyperlipidemia patients were divided into four statin cohorts (statin use >365 days; statin use 181-365 days; statin use 91-180 days; and statin use 31-90 days) and one control cohort (cohort that used no statins). The primary end point was the diagnosis of bladder cancer. The risks of bladder cancer for all subjects and different gender in these newly diagnosed hyperlipidemia patients were estimated by using the multivariable Cox proportional hazards regression model.
Results:
Multivariable Cox proportional hazards regression analyses demonstrated that bladder cancer risk in the cohort used statins for >365 days was significantly lower than the control cohort (adjusted hazard ratio: 0.54, 95% confidence interval: 0.35~0.82, p=0.004). Trend analysis revealed that the effects of statin treatment on decreasing bladder cancer risk were significantly related to statin treatment duration in women adjusted hazard ratio (p=0.013) but not in men (p=0.096).
Conclusion:
Hyperlipidemia female patients with long term statin treatment (more than 365 days) associated with a reduced risk of bladder cancer.