術中排多癌(mitomycin-C)膀胱灌注在機器手臂輔助腎臟輸尿管及膀胱袖口切除術與膀胱內腫瘤復發的相關性
楊有容、黃志平
中國醫藥大學附設醫院 泌尿部
Association of bladder mitomycin-C instillation during robotic nephroureterectomy with bladder cuff excision with bladder recurrence.
You-Rong Yang, Chi-Ping Huang
China Medical University Hospital, Taichung, Taiwan
Purpose: Nephroureterectomy (NU) with bladder cuff excision (BCE) remains the standard surgical treatment for upper tract urothelial carcinoma (UTUC). Here we evaluated the association of intraoperative mitomycin-C (MMC) instillation in robotic NUBCE with bladder recurrence.
Materials and Methods: we retrospectively review patients in a single team who underwent robotic NUBCE within 2016/01/01 to 2019/01/31 and received intraoperative MMC instillation. Patient with previous bladder urothelial carcinoma, status post kidney transplantation was excluded. We analyzed the bladder tumor recurrence (BTR) rate after surgery.
Results: fifteen patients were included in our study. Patient with previous bladder urothelial carcinoma, status post kidney transplantation were excluded. The median length of follow-up for each group was 268.5 days. Only one patient was found to have bladder recurrence during follow up, and the BTR rate was 6%.
Conclusions: Our results suggest that intraoperative MMC instillation may have benefit to decrease the rate of BTR in patients received robotic NUBCE for UTUC, and there was no obvious related complication in our study. Further larger, prospective evaluation with longer follow-up time, standardized duration of intraoperative MMC instillation will be indispensable to continue to improve the BTR following robotic NUBCE for UTUC.