Resveratrol was reported to have anti-cancer effect by Jayafilake in 1993( Kinase inhibitors from Polygonum cuspidatum. J Nat Prod 56: 1805–1810).then

The cancer chemopreventive properties of resveratrol were discovered in 1997 by Jung and colleagues, when they demonstrated the anti-initiation, anti-promotion, and anti-progression activities of resveratrol in different models. M. Jang, L. Cai, G. O. Udeani, K.V. Slowing, C.F. Thomas, C.W. Beecher, H.H. Fong, N.R. Farnsworth, A.D. Kinghorn, R.G. Mehta, R.C. Moon, J.M. PezzutoCancer chemopreventive activity of resveratrol, a natural product derived from grapes.Science, 275 (1997),Multiple biochemical and molecular actions seem to contribute to resveratrol effects against precancerous or cancer cells. Resveratrol affects all three discrete stages of carcinogenesis (initiation, promotion, and progression) by modulating signal transduction pathways that control cell division and growth, apoptosis, inflammation, angiogenesis, and metastasis.

Research has shown that resveratrol has the ability to deeply penetrate the center of a cell's nucleus, allowing the DNA to repair free radical damage that might otherwise contribute to cancerous growth.Further, resveratrol's anti-inflammatory properties help prevent certain enzymes from forming that trigger tumor development. It also helps cut down cell reproduction, which helps reduce the number of cell divisions that could contribute to the progression of cancer cell growth.

●The benefit of resveratrol on bladder cancer was seen in this case.