Subjective symptom improvement of silodosin treatment for BPH patients with unsatisfactory response to initial ɑ1 blocker
針對前列腺肥大病人經甲型阻斷劑治療不滿意反應接受 silodosin治療後的症狀改善
Chia-Wei Cheng, Chien-Hui Ou
鄭嘉緯, 歐建慧
Department of Urology, Medical College and Hospital, National Cheng-Kung University, Tainan, Taiwan.
國立成功大學醫學院附設醫院泌尿部
Purpose: To evaluate subjective symptom improvement of silodosin treatment for BPH patients with unsatisfactory response to initial ɑ1 blocker.
Methods: 50 BPH patients with unsatisfactory response to initial ɑ1 blocker were included in this study. IPSS were recorded before and after administration of 4 weeks of silodosin. No drug withdrawal period was provided when switching the drug.
We evaluate subjective improvement of silodosin treatment acoording to the International Prostate Symptom Score.
Results: 28 patients (56 % ) had subjectively improved the International Prostate Symptom Score total score but 22 patients failed to have symptom improvement. Comparison of changes revealed that silodosin showed significant improvement of nocturia. The most frequent adverse drug reaction was ejaculatory disorder with silodosin.
Conclusions: In BPH/LUTS patients, silodosin exhibits some efficacy in improving subjective symptoms especially in nocturia for BPH patients with unsatisfactory response to initial ɑ1 blocker