以Galactin-1蛋白質異常表現做為膀胱泌尿上皮癌之預後因子
謝昆霖1、蘇家震1、沈坤宏1、吳定峰2
1奇美醫院 外科部 泌尿外科
2南台科技大學 生物科技系
Galactin-1 Dysregulation is Predict Factor to Prognosis of Urinary Bladder Urothelial Carcinoma
Kun-Lin Hsieh1, Chi-Cheng Su1, Kun-Hung Shen1, Ting-Feng Wu2
1Divisions of Urology, Department of Surgery, Chi Mei Medical Center
2Department of Biotechnology, Southern Taiwan University of Science and Technology
Purpose:
Galactin-1 plays an important role in oncogenic processes. In several literatures, it has been studied that Galactin-1 is highly related to some cancers, including hepatocellular carcinoma and breast cancer. In our present study, we try to clarify the relationship between Galactin-1 over-expression and prognosis of urinary bladder urothelial carcinoma (UC).
Materials and Methods:
We reviewed 185 patients who had bladder UC and received transurethral resection of bladder tumor. The spacemen was re-examed by pathologist and further survey about cytoplasmic galactin-1 immunoexpression was performed. Then we correlate the laboratory data to clinical disease prognosis under statistical analyses.
Results:
Positive galectin-1 immunoexpression in tumor significantly links with increment of pT status (p=0.0295) as well as histological grade (p=0.037), the presence of vascular invasion (p=0.0287), nodal status (p=0.0012), high mitotic activity (p=0.0015) and tumor necrosis (p=0.0246). Galectin-1 over-expression in tumor cell predicts the disease-specific survival in univariate (P=0.0002) and multivariate analysis (P=0.03, HR=2.438). Besides, gene of galactine-1 (as LGALS1 gene) amplification is also linked to disease-specific survival rate (P=0.0006).
Conclusions:
Galectin-1 over-expression is an adverse factor to predict the prognosis of urinary bladder UC. It may help us about clinical decision making and outcome prediction. Further relationship between urinary bladder UC and galactin-1 can be studied on the base of this present study.