嗜中性球與淋巴球比率與根除性膀胱切除手術預後之關連性
黃靖崴 張英勛 馮思中 虞凱傑 林柏宏 劉忠一 莊正鏗
林口長庚紀念醫院外科部泌尿外科
The Prognostic Value of Neutrophil And Lymphocyte Ratio in Patient Receiving Radical Cystectomy Operations
Ching-wei Huang, Ying-Hsu Chang
Department of Surgery, Division of Urology, Chang Gung Memorial Hospital at Linkou
Purpose:
To identify Neutrophil/Lymphocyte ratio(NLR) as a prognostic predictor influencing long term survival for patient undergoing radical cystectomy with different urothelial carcinoma stages
Materials and Methods:
We obtained 163 patients who admitted for urothelial carcinoma and underwent radical cystectomy during 2005-2008 in Linkou Chang-Gung Memorial Hospital. The preoperative factors including gender, tumor pathology, tumor size, pathological characteristics and pre-OP lab data were analysed. The paired t-test was used to analyze associations between categorical variables. Multivariate analysis was performed. Significance level was set at p<0.05. All stastical analysis was done with SPSS for MAC.
Results:
This study included total 163 cases with mean patient age as 66.6 years old. The most common cell type as infiltrating urothelial carcinoma and 5-year overall survival rate was 43%. We obtained pre-OP lab data for calculating NLR and set different cut points for comparing significance in different groups. When NLR was set as 3, there was significance survival difference between two groups(NLR>3, Overall Survival=45.92M; NLR<3, OS=56.62M). However, when moving on into multivariate analysis, the NLR was not an independent prognostic factor for patient receiving radical cystectomies. (HR=1.06, 95% CI=0.45-2.50, p=0.90)
Conclusion:
In patient undergoing radical cystectomies, NLR showed overall survival difference between group when cut point was set at 3. However, further multivariate analysis failed to showed independent prognostic power of NLR in current patient cohort.