幽門螺旋桿菌抗原於攝護腺炎之角色探討
何東儒12、陳志碩、林威宇、黃雲慶、林健煇
長庚醫院嘉義分院 外科部 泌尿科；1長庚大學臨床 醫學研究所 2長庚科技大學 護理系，
The Role of Helicobacter pylori antigen in Chronic Prostatitis
Dong-Ru Ho12, Chih-Shou Chen, Wei-Yu Lin, Yun-Chin Huang, Jian-Hui Lin
Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Taiwan
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taiwan
Department of Nursing, Chang Gung University of Science and Technology, Taiwan
Purpose: Epidemiological evidences had shown that patients with Helicobacter pylori (H.p.) infection had more urological prostatitic diseases. And chronic prostatitis patients had significantly higher positive anti-H.p. rate. Therefore, we investigated the possible role of H.p. in chronic prostatitis.
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Materials and Methods: We set up chronic prostatitis model by introducing H.p. into male rats. Physiological bladder changes along with pain sensitivity in scrotum and tail base were evaluated with cystometrogram and Von Frey filament correspondently. Local prostatic inflammation was checked with Western blot and immunohistochemical stain. Systemic inflammation was evaluated by checking cytokines in spleen. .
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Results: Hypersensitivity in rat scrotum confirmed the development of chronic prostatitis. Tail base sensitivity showed less significant correspondence. There was significant difference caspase 1 expression in H.p. antigen stimulated prostate. Matured caspase 1 ratio also increased. However, local IL-1b did not seem to have significance. Systemic inflammation was confirmed by significantly increased TNF-alpha in spleen protein extraction.
Conclusions: H.p. antigen may induce local and systemic inflammation. Local effect in prostate induces chronic prostatitis-like response. Further investigation on the systemic effect of H.p. antigen may be necessary to confirm its immunological role on chronic prostatitis.