VEGF 2578C>A 多態性與代謝症候群以及勃起功能障礙之關係

劉致毅1,2、耿俊閎1,2、詹鎮豪1,2、王巽玄1,2、沈榮宗1、曹曜軒1,2、吳怡萱1,2、劉家駒2、黃書彬2、李永進1,2

 1高雄市立小港醫院泌尿科； 2高雄醫學大學附設中和紀念醫院 泌尿部

The Association of VEGF 2578C>A Polymorphism with Metabolic Syndrome and Erectile Dysfunction

Chih I Liu1,2, Jiun Hung Geng1,2, Jhen Hao Jhan1,2, Hsun Shuan Wang1,2, Jung Tsung Shen1,2, Yao Hsuan Tsao1,2, Yi Hsuan Wu1,2, Chia Chu Liu2, Shu Pin Huang2, Yung Chin Lee1,2

 1Depratment of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan;  2Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung,Taiwan

Purpose: Accumulated evidences suggests a link between vascular endothelial growth factor (VGEF), erectile function and metabolic syndrome because VEGF can alter the physiologic pathways involved in the regulation of endothelial cell proliferation. The impaired ability of endothelial cell proliferation may provide a common pathophysiological mechanism in the development of metabolic syndrome (MtS) and erectile dysfunction (ED). The aim of this article was to investigate the genetic susceptibility of VEGF 2578C>A polymorphism underlying the development of both disorders.

Materials and Methods: A total of 596 subjects with a mean (standard deviation) age of 55.5 years (4.3) were enrolled during a free health screening. Complete clinical data and questionnaires were taken for all subjects. Multivariate logistic regression analysis was used to determine the independent predictors of MtS and ED. The VEGF 2578C>A polymorphism was determined using a polymerase chain reaction-restriction fragment length polymorphism method. The definition of MtS was according to the modified criteria developed by the Bureau of Health Promotion in Taiwan. Patients with ED were defined as those having a five-item International Index of Erectile Function (IIEF-5) <21.

Results: Our results showed that the VEGF 2578A allele carriers had significantly higher prevalence of MtS and ED (odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.32 to 2.60, P = 0.02 and OR = 1.61, 95% CI = 1.16 to 2.24, P = 0.005, respectively) after adjustment for each other and age. Also the A allele carriers had significantly lower IIEF-5 score and more MtS components than C allele carriers (P = 0.001 and P < 0.001, respectively), which were significantly associated with an increment of the A allele number (P < 0.05).

Conclusions: The VEGF 2578A allele carriers are at greater risk for both MtS and ED, suggesting that VEGF 2578A gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders.