尿路结石作为勃起功能障碍的潜在危险因素：一项回顾性队列研究

Urolithiasis as a Potential Risk Factor for Erectile Dysfunction: A Retrospective Cohort Study

朝仓聪¹，松井祐辉¹，深具隆志¹

1)    昭和医科大学泌尿科学讲座

Satoshi Asakura¹, Yuki Matsui¹, Takashi Fukagai¹

1)    Showa Medical University school of medicine

Objective: Erectile dysfunction (ED) is closely linked to cardiometabolic disorders, while urolithiasis is also associated with metabolic syndrome and systemic inflammatory alterations. Despite these shared risk factors, the relationship between ED and urolithiasis remains unclear. This study aimed to investigate the association between ED and urolithiasis using clinical data from patients treated at our institution.

Methods: We conducted a retrospective case-control study including 38 male patients diagnosed with urolithiasis and 32 male controls without stone disease who were admitted to our clinic. Patients with severe cardiovascular disease, endocrine disorders, or neurological conditions affecting erectile function were excluded. Erectile function was evaluated using the International Index of Erectile Function (IIEF-15). Clinical and demographic data were collected from medical records, and appropriate statistical analyses were performed to compare variables between groups.

Results: Erectile dysfunction was observed in 17 of 38 patients with urolithiasis (44.7%), whereas only 6 of 32 controls (18.8%) reported mild ED and none had moderate or severe ED. Among patients with urolithiasis, 6 (15.8%) had mild ED, 5 (13.2%) had moderate ED, and 6 (15.8%) had severe ED. The prevalence and severity of ED were significantly higher in the urolithiasis group than in the controls (p < 0.05).

Conclusion: ED was significantly more prevalent among patients with urolithiasis, suggesting a shared systemic background. Routine assessment of erectile function should be considered in men with urolithiasis to facilitate early detection and guide lifestyle and metabolic management.