Association Between One-Year Testosterone Change and Subcutaneous Fat Reduction in Obese Men Undergoing Weight Loss

Sih-Han Chen ^1,2 Jian-Han Chen ^3,4 Yao-Chun Hsu ^2,5
1. Department of Urology, E-Da Hospital, Kaohsiung, Taiwan.

2. Graduate Institute of Medicine, Medical College, I-Shou University, Kaohsiung, Taiwan.

3. Division of General Surgery, Yanchao Dist, E-Da Hospital, No. 1, Yida Rd, Kaohsiung City 824, Taiwan

4. Bariatric and Metabolism International Surgery Center, E-Da Hospital, Kaohsiung, Taiwan

5. Division of Gastroenterology and Hepatology, E-Da Hospital

一年後睪固酮變化與皮下脂肪減少之關聯性：肥胖男性減重族群之研究
陳思翰^1,2 陳建翰^3,4 許耀峻^2,5

1.      義大醫院泌尿科

2.      義守大學醫學研究所

3.      義大醫院一般外科

4.      義大醫院減重暨代謝手術國際中心

5.      義大醫院肝膽腸胃科

Background: In obese men, weight reduction can improve serum testosterone, but it is unclear which adipose compartment best reflects this change.

Objective: To evaluate the association between 1-year change in serum testosterone and MRI-derived fat changes in obese men.

Material and Methods: We reviewed 23 obese men who had baseline and 12-month measurements of total testosterone and abdominal MRI. The 12-month testosterone change (ΔT) was entered as the independent variable in separate linear regression models with changes in subcutaneous fat, visceral fat, and liver fat as dependent variables.

Results: ΔT was significantly and inversely associated with subcutaneous fat change (standardized β = –0.439, p = 0.036), explaining 19.2% of the variance. ΔT was not significantly associated with visceral fat change (β = –0.217, p = 0.319) or liver fat change (β = 0.038, p = 0.867).

Conclusions: In this cohort of obese men, a greater 1-year increase in testosterone was associated with a greater reduction in subcutaneous fat, but not with changes in visceral or liver fat.