MicroRNA-210的過度表現與上泌尿道上皮癌之相關性
柯宏龍1,2,3、李威明1,2,3,4、林慧惠2,3、徐偉齊1,2,3、許雅玲1、張玲麗1,6、黃俊農1,2,3、
李經家1,2,3,5、張欣萍2,3、葉信志1,2,3,4、李建逢7、吳文正1,2,3,5
高雄醫學大學 醫學研究所1 泌尿學科2 微生物學科6
高雄醫學大學附設醫院泌尿科3、衛福部屏東醫院泌尿科4、大同醫院泌尿科5
奇美醫院病理科7
Hypoxia-regulated microRAN-210 overexpression is associated with tumor development and progression in upper tract urothelial carcinoma
Hung-Lung Ke1,2,3, Wei-Ming Li1,2,3,4, Hui-Hui Lin2,3, Wei-Chi Hsu1,2,3, Ya-Ling Hsu1, Lin-Li Chang 1,6, Chun-Nung Huang 1,2,3, Ching-Chia Li 1,2,3,5, Hsin-Ping Chang2,3, Hsin-Chih Yeh1,2,3,4, Chien‑Feng Li7, Wen-Jeng Wu1,2,3,5
1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 2Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, 3Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 4Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung, 5Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, 6Department of Microbiology, School of Medicine, College of Medicine, Kaohsiung Medical University, 7Department of Pathology, Chi Mei Medical Center
Purpose: Hypoxia has been proved to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we will evaluate the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC).
Materials and Methods: Eighty-three UTUC patients were recruited into this study. All of them provided cancer tissues and 50 of them also provided non-cancer urothelium. Clinicopathologic data were collected from reviewing medical records. MiR-210 and hypoxia-inducible factor 1α (HIF-1α) expression were examined by quantitative real-time polymerase chain reaction. The relationship between miR-210, HIF-1α expression and clinicopathologic variables was analyzed statistically.
Results: MiR-210 was overexpressed in UTUC compared to non-cancer urothelium (p < 0.001), and also upregulated in high stage and high grade tumors (p = 0.017 and 0.049, respectively). HIF-1α was overexpressed in UTUC and positively correlated with miR-210 expression (r = 0.442, p = 0.001).
Conclusion: MiR-210 and HIF-1α were both involved in promoting UTUC carcinogenesis. MiR-210 was also correlated with tumor progression. Further studies were needed to clarify underlying mechanism.