Leptin receptor的過度表現與上泌尿道上皮癌之相關性
李怡琛1,2、吳文正2,3,4,5、林慧惠3,4、李威明1,2,3,4,6 、黃俊農2,3,4、徐偉齊2,3,4、張玲麗2,7、
李經家2,3,4,5、葉信志2,3,4,5、李建逢8、柯宏龍2,3,4
高雄醫學大學 解剖科、醫學研究所1 泌尿學科2微生物學科6
高雄醫學大學附設醫院泌尿科3、衛福部屏東醫院泌尿科4、大同醫院泌尿科5
奇美醫院病理科7
Prognostic value of leptin receptor overexpression in upper tract urothelial carcinomas in Taiwan
Yi-Chen Lee1,2, Wen-Jeng Wu2,3,4,5, Hui-Hui Lin3,4, Wei-Ming Li2,3,4,6, Chun-Nung Huang2,3,4, Wei-Chi Hsu2,3,4, Lin-Li Chang2,7, Ching-Chia Li2,3,4,5, Hsin-Chih Yeh2,3,4,5, Chien-Feng Li8, Hung-Lung Ke2,3,4
1Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, 2Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 3Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 4Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, 5Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, 6Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung, 7Department of Microbiology, Kaohsiung Medical University, 8Department of Pathology, Chi-Mei Medical Center, Tainan
Purpose: Leptin and its receptor (LEPR) are key players in the regulation of energy balance and body weight control and act as a growth factor for specific organs in both normal and disease states. However, LEPR accumulation may be involved in carcinogenesis, progression, and metastasis in many cancers. This study evaluated the clinical significance of LEPR expression in upper tract urothelial carcinoma (UTUC).
Materials and methods: LEPR expression was examined in 110 tissue samples from patients with UTUC, using immunohistochemistry, and an analysis was performed to identify evidence of association between LEPR expression and different clinicopathological variables.
Results: LEPR expression was significantly correlated with patients with increased body mass index (BMI) (P < 0.001) and high serum creatinine levels (P = 0.005). We found, using the log-rank test, that high LEPR expression was associated with poor recurrence-free (P = 0.009) and cancer-specific survival (P = 0.001). This finding was supported by our results using Cox regression analysis, which showed that LEPR expression was an independent predictor of poor recurrence-free survival (hazard ratio = 2.55, P = 0.011) and cancer-specific survival (hazard ratio = 2.26, P = 0.006).
Conclusions: Our findings indicate that LEPR expression is a potential biomarker for predicting patient survival in UTUC. Further study is necessary to investigate the role of LEPR in carcinogenesis of upper tract urothelial carcinoma.