病例報告及文獻回顧: 6例膀胱淋巴瘤
方楚文1、廖建華1、沈坤宏1、黃冠華2、劉建良1、蘇家震1
1奇美醫學中心外科部泌尿外科
2奇美醫學中心外科部泌尿腫瘤科

Bladder lymphoma: Cases study of six patients and review of the literature
Chu-Wen Fang1, Alex Chien-Hwa Liao1, Kun-Hung Shen1, Steven K. Huang2, Chien-Liang Liu1, Chia-Cheng Su1
1 Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
22Division of Uro-oncology, Department of Surgery, Chi Mei Medical Center, Tainan,

Abstract

Objectives:
Lymphoma of the urinary bladder (LUB) is extremely rare and is estimated less than 100 case reports among literature. The primary LUB represent about 0.2% of all extra- nodal non-Hodgkin's lymphoma, whereas secondary LUB occurs in 10% to 25% of leukemia/lymphomas. The primary LUB was female predominance and mostly occurred in middle-age women. The most frequently reported type of LUB is mucosa-associated lymphoid tissue (MALT) lymphoma, while diffuse large B-cell lymphoma (DLBCL) is also common and may transformed from MALT. Herein, we report our experience in the management of LUB in six patients.     
Patients:
Retrospectively, we reviewed the charts of patients who admitted to our hospital with discharge diagnosis of LUB. The demographics, disease symptoms, pathology reports, tumor makers and treatment strategy were collected for study. The abstracted data from the chart contained no identification of patient information.
Results:
A total of six patients were enrolled, there were two males and four females. The mean age was 80 ± 15.9 y/o. There were four patients with primary LUB and two patients with secondary LUB. The symptom of painless hematuria was presented in all six patients while obstructive uropathy was noted in three patients. The pathologic report showed four DLBCL and two Burkitt lymphoma. The tumor marker showed expression of CD 20 in all patients.
Summary:
Lymphoma of the urinary bladder is extremely rare. The aged patients might be benefited from early diagnosis and adequate treatment plans. We reported our experiences in the management of LUB in six patients and review of literatures.